Beilstein J. Nanotechnol.2017,8, 1457–1468, doi:10.3762/bjnano.8.145
agents for gene delivery in the form of nanoplexes. In this study, the potential of polycationic, amphiphiliccyclodextrin nanoparticles were evaluated in comparison to non-ionic amphiphilic cyclodextrins and core–shell type cyclodextrin nanoparticles for paclitaxel delivery to breast tumors. Pre
-cytotoxic against L929 mouse fibroblast cell line. In addition, paclitaxel-loaded nanoparticles have a significant anticancer effect against MCF-7 human breast cancer cell line as compared with a paclitaxel solution in DMSO.
Conclusion: According to the results of this study, both amphiphiliccyclodextrin
derivatives provide suitable nanometer-sized drug delivery systems for safe and efficient intravenous paclitaxel delivery for chemotherapy. In the light of these studies, it can be said that amphiphiliccyclodextrin nanoparticles of different surface charge can be considered as a promising alternative for
PDF
Figure 1:
Schematic representation of amphiphilic 6OCaproβCD (a), amphiphilic PC βCDC6 (b), chitosan (c) and ...